ENDOCRYL® - N-Butyl-2 Cyanoacrylate was officially launched at the SGEI Annual
Conference in Kolkatta on 27th March,2005 by ‘ Prof. Nib Soehendra “ from Germany.
He has been one of the world pioneers in using N-Butyl-2 Cyanoacrylate for Gastroen-
-terological diseases.

Introduction
N-Butyl-2-cyanoacrylate is a liquid compound that polymerizes rapidly in the presence
of moisture and is used for the closure of uncomplicated skin lacerations. It is a surgical
adhesive that provide another option for wound closure. When compared to sutures
N-Butyl-2-cyanoacrylate is found to be as effective as sutures in low tension lacerations
and for the attachment of some full thick ness skin grafts. 

Characteristics of N-Butyl-2-cyanoacrylate
N-Butyl-2-cyanoacrylate is a monomer which when comes into contact with moisture of
the skin’s surface chemically changes into a polymer that binds to the top epithelial layer.
This polymer forms a cyanoacrylate bridge, binding the two wound edges together and
allowing normal healing to occur below. N-Butyl-2-cyanoacrylate has also been shown to
have antimicrobial properties. 

N-Butyl-2-cyanoacrylate was developed in the 1970s, as the first adhesive to have
negligible tissue toxicity and good bonding strength, as well as acceptable wound cosmesis. 

It has been observed that N-Butyl-2-cyanoacrylate has been used: 
• In cartilage and bone grafting, coating of corneal ulcers in ophthalmology,
• Repair of damaged ossicles in otolaryngology,
• Coating of aphthous ulcers,
• Embolization of gastrointestinal varices and embolization in neuro vascular surgery.